The matrilineal ancestry of Nepali populations The maternal ancestry of Nepal is a mixture of the South and East-Asian population It is widely accepted that the modern human originated in Africa around 200 000 years ago (KYA) and migrated out of Africa between 60 and 70 KYA. Several populations arose in this process, and each has its own evolutionary history. Genetic drift, endogamy, admixture, isolation, and natural selection are a few evolutionary processes that have contributed to genetic diversity among human populations worldwide, including susceptibility and resistance to genetic diseases, infectious diseases, therapeutic response to drugs, and other conditions. Understanding these phenomena is much more relevant in a country like Nepal, which has one of the world's richest ethnic, cultural, linguistic, and social diversity and harbors several anthropologically well-deļ¬ned populations. In simple terms, there are populations in Nepal that are phenotypically similar to East A